Effect of chemotherapeutic agents on chromosomes of patients with lung cancer.

in leukocytes both in vivo and in vitro. Similar studies have been carried out on the in vitro effect of chemotherapeutic drugs; however, relatively few studies have been reported on the in vivo effect of chemotherapeutic drugs on chromosomes.’11 Of the latter group, there were only three cases of bronchogenic carcinoma, all treated with nitrogen mustard.2’9 This study reports chromosome changes in 20 additional patients with bronchogemc carcinoma who received chemotherapy as their only specific treatment. RESULTS